Mice that had been fed a ketogenic diet for 7 days before infection had improved survival rate relative to mice on a normal diet.
The researchers fed a group of mice infected with influenza a keto diet containing less than 1 percent carbs. Another group of infected mice received a standard diet with 58 percent carbs.
Study Name:Ketogenic diet activates protective γδ T cell responses against influenza virus infection.
The researchers fed flu-infected mice a keto diet that contained less than 1 percent carbohydrates. One group of infected mice received a standard diet of 58 percent carbohydrates, another group received a normal diet. Mice fed ketogenic diets 7 days after infection had better survival, protected against body weight loss, and had a significantly lower risk of death than the control group compared to mice fed normal diets.
According to a Yale University study published November 15 in the journal Science Immunology, mice fed a low-carbohydrate, ketogenic diet were able to fight the flu virus more effectively than mice fed a high-carbohydrate diet.
T cells in the lungs that had not previously been associated with the immune system’s response to flu. The ketogenic diet increased the number of airway cells that can effectively catch the virus, the researchers reported. The researchers fed flu-infected mice a keto diet that contained less than 1 percent carbohydrates. Another group of infected mice were given a standard diet of 58 percent carbohydrates.
The researchers also found that the keto diet provided protection against influenza viruses in mice specifically bred with gamma delta T cells. This confirmed that these cells play a crucial role in the defence against the flu. The ketogenic diet boosted the production of immune system cells that produce mucus from cells in the lungs. The increase in mucous membranes helps capture and eliminate influenza viruses within the system, according to the researchers.
In this study it was shown that the keto diet protects mice from deadly IAV infections and diseases. The morbidity and mortality associated with infection from the spread of influenza viruses is a key global public health concern and requires the development of new therapies to reduce the severity of IV infection.
T cells in the lungs to improve barrier function and thus strengthen antiviral resistance. T cells require metabolic adaptation to ketogenic nutrition and provide a chemical ketone body substrate that bypasses liver ketogenesis and protects against infection. KD – mediated immune-metabolic integration therefore represents a novel approach to the prevention and alleviation of influenza diseases.
This research project will probably come from a research team similar to the one in the Iwasaki laboratory. Ryan Molony is working to find out whether an immune system activator called inflammasome blocks the formation of inflammasomes in its host. Emily Goldberg has collaborated with the Dixit lab, which has shown that a ketogenic diet blocks the formation and activation of the immune pathway by blocking the production of an inflammatory cytokine, IL-6.
Specifically, the researchers found that a ketogenic diet triggers the formation of immune system cells that produce mucus in the cellular membrane of the lungs, whereas a carbohydrate-rich diet does not. The two wonder if the diet could affect the production of T cells, an important immune cell type in lung cancer. A team of researchers from the University of California, San Diego School of Medicine showed that mice on a ketogenic diet and infected with influenza viruses had lower production and activation of IL-6 in their lungs. In mice bred with genes that code for gamma delta T cells and on a low-fat diet, ketogenic foods provided protection against influenza viruses.
Dixit said the study shows that ketones, the fat the body burns to produce ketone bodies after eating, can boost the immune system to fight flu infections.